Behavioural and functional anatomical correlates of deception in humans

Spence, Sean A.; Farrow, Tom F. D.; Herford, Amy E.; Wilkinson, Iain D.; Zheng, Ying; Woodruff, Peter W. R.

Neuroreport:
17 September 2001 - Volume 12 - Issue 13 - pp 2849-2853
Brain Imaging

Abstract: Brain activity in humans telling lies has yet to be elucidated. We developed an objective approach to its investigation, utilizing a computer-based interrogation and fMRI. Interrogatory questions probed recent episodic memory in 30 volunteers studied outside and 10 volunteers studied inside the MR scanner. In a counter-balanced design subjects answered specified questions both truthfully and with lies. Lying was associated with longer response times (p < 0.001) and greater activity in bilateral ventrolateral prefrontal cortices (p < 0.05, corrected). These findings were replicated using an alternative protocol. Ventrolateral prefrontal cortex may be engaged in generating lies or withholding the truth.

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